Construction of Smart Grid Load Forecast Model by Edge Computing

This research aims to minimize the unnecessary resource consumption by intelligent Power Grid Systems (PGSs). Edge Computing (EC) technology is used to forecast PGS load and optimize the PGS load forecasting model. Following a literature review of EC and Internet of Things (IoT)-native edge devices, an intelligent PGS-oriented Resource Management Scheme (RMS) and PGS load forecasting model are proposed based on task offloading. Simultaneously, an online delay-aware power Resource Allocation Algorithm (RAA) is developed for EC architecture. Finally, comparing three algorithms corroborate that the system overhead decreases significantly with the model iteration. From the 40th iteration, the system overhead stabilizes. Moreover, given no more than 50 users, the average user delay of the proposed delay-aware power RAA is less than 13 s. The average delay of the proposed algorithm is better than that of the other two algorithms. This research contributes to optimizing intelligent PGS in smart cities and improving power transmission efficiency

Finetuning Text-to-Image Diffusion Models for Fairness

The rapid adoption of text-to-image diffusion models in society underscores an urgent need to address their biases. Without interventions, these biases could propagate a distorted worldview and limit opportunities for minority groups. In this work, we frame fairness as a distributional alignment problem. Our solution consists of two main technical contributions: (1) a distributional alignment loss that steers specific characteristics of the generated images towards a user-defined target distribution, and (2) biased direct finetuning of diffusion model's sampling process, which leverages a biased gradient to more effectively optimize losses defined on the generated images. Empirically, our method markedly reduces gender, racial, and their intersectional biases for occupational prompts. Gender bias is significantly reduced even when finetuning just five soft tokens. Crucially, our method supports diverse perspectives of fairness beyond absolute equality, which is demonstrated by controlling age to a $75\%$ young and $25\%$ old distribution while simultaneously debiasing gender and race. Finally, our method is scalable: it can debias multiple concepts at once by simply including these prompts in the finetuning data. We hope our work facilitates the social alignment of T2I generative AI. We will share code and various debiased diffusion model adaptors.Comment: preprint under revie

Application and design of a new quick-opening seal device connected by D-shape shearing bolts in hypersonic wind tunnel

Paper presented at the 5th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, South Africa, 1-4 July, 2007.Application and design of a new quick-opening seal device connected by D-shape shearing bolts in hypersonic wind tunnel is introduced in this paper. This device is compact in structure, reliable in sealing, easy in assembly and disassembly, appropriate for end closure of pressure vessels or joints of pipes. Mechanical models are established for all major components, and strength calculation formulas are obtained which can be used for the design of the structure.cs201

HPV E6 induces eIF4E transcription to promote the proliferation and migration of cervical cancer

AbstractIncreasing evidence has placed eukaryotic translation initiation factor 4E (eIF4E) at the hub of tumor development and progression. Several studies have reported that eIF4E is over-expressed in cervical cancer; however, the mechanism remains elusive. The results of this study further confirm over-expression of eIF4E in cervical cancer tumors and cell lines, and we have discovered that the transcription of eIF4E is induced by protein E6 of the human papillomavirus (HPV). Moreover, regulation of eIF4E by E6 significantly influences cell proliferation, the cell cycle, migration, and apoptosis. Therefore, eIF4E emerges as a key player in tumor development and progression and a potential target for CC treatment and prevention

Assessment of gene order computing methods for Alzheimer’s disease

This article was originally published by BMC Medical Genomics in 2013. doi:10.1186/1755-8794-6-S1-S8Background: Computational genomics of Alzheimer disease (AD), the most common form of senile dementia, is a nascent field in AD research. The field includes AD gene clustering by computing gene order which generates higher quality gene clustering patterns than most other clustering methods. However, there are few available gene order computing methods such as Genetic Algorithm (GA) and Ant Colony Optimization (ACO). Further, their performance in gene order computation using AD microarray data is not known. We thus set forth to evaluate the performances of current gene order computing methods with different distance formulas, and to identify additional features associated with gene order computation. Methods: Using different distance formulas- Pearson distance and Euclidean distance, the squared Euclidean distance, and other conditions, gene orders were calculated by ACO and GA (including standard GA and improved GA) methods, respectively. The qualities of the gene orders were compared, and new features from the calculated gene orders were identified. Results: Compared to the GA methods tested in this study, ACO fits the AD microarray data the best when calculating gene order. In addition, the following features were revealed: different distance formulas generated a different quality of gene order, and the commonly used Pearson distance was not the best distance formula when used with both GA and ACO methods for AD microarray data. Conclusion: Compared with Pearson distance and Euclidean distance, the squared Euclidean distance generated the best quality gene order computed by GA and ACO methods.The work was supported by the BWH Radiology and MGH Psychiatry research funds (to X. Huang) and the Technology Innovation fund (No. 09zz028) of Key Developing Program from Education Department of Sichuan Province, ChinaPearson distanc

Single-cell resolution imaging of retinal ganglion cell apoptosis in vivo using a cell-penetrating caspase-activatable peptide probe

Peptide probes for imaging retinal ganglion cell (RGC) apoptosis consist of a cell-penetrating peptide targeting moiety and a fluorophore-quencher pair flanking an effector caspase consensus sequence. Using ex vivo fluorescence imaging, we previously validated the capacity of these probes to identify apoptotic RGCs in cell culture and in an in vivo rat model of N-methyl- D-aspartate (NMDA)-induced neurotoxicity. Herein, using TcapQ488, a new probe designed and synthesized for compatibility with clinically-relevant imaging instruments, and real time imaging of a live rat RGC degeneration model, we fully characterized time- and dose-dependent probe activation, signal-to-noise ratios, and probe safety profiles in vivo. Adult rats received intravitreal injections of four NMDA concentrations followed by varying TcapQ488 doses. Fluorescence fundus imaging was performed sequentially in vivo using a confocal scanning laser ophthalmoscope and individual RGCs displaying activated probe were counted and analyzed. Rats also underwent electroretinography following intravitreal injection of probe. In vivo fluorescence fundus imaging revealed distinct single-cell probe activation as an indicator of RGC apoptosis induced by intravitreal NMDA injection that corresponded to the identical cells observed in retinal flat mounts of the same eye. Peak activation of probe in vivo was detected 12 hours post probe injection. Detectable fluorescent RGCs increased with increasing NMDA concentration; sensitivity of detection generally increased with increasing TcapQ488 dose until saturating at 0.387 nmol. Electroretinography following intravitreal injections of TcapQ488 showed no significant difference compared with control injections. We optimized the signal-to-noise ratio of a caspase-activatable cell penetrating peptide probe for quantitative non-invasive detection of RGC apoptosis in vivo. Full characterization of probe performance in this setting creates an important in vivo imaging standard for functional evaluation of future probe analogues and provides a basis for extending this strategy into glaucoma-specific animal models